Isoniazid was found to alter central monoaminergic neurotransmission . Although aldehyde dehydrogenase was inhibited with coadministration, blood acetaldehyde levels were not increased. Different factors may increase the risk of experiencing severe reactions from mixing alcohol and metronidazole.

Alcohol can increase the risk of liver damage.GriseofulvinTalk with your doctor before you drink alcohol.Avoid alcoholic beverages. Avoid alcoholic beverages while using this medication.This medication may interact with alcohol. Avoid alcoholic drinks.EthambutolNo warningAlcohol may increase the risk of liver disease.

Of the 55 patients in that study, 30 received ethionamide and three patients developed parenchymal liver damage. Two of these cases may have been related to the concurrent use of pyrazinamide . The chance of experiencing a disulfiram-like reaction to metronidazole and alcohol varies from person to person. But because doctors cannot determine a person’s risk of this reaction, everyone should avoid drinking alcohol while taking Flagyl. Alcohol can cause reactions in addition to the regular side effects of this drug.

flagyl and alcohol

For this reason, you also shouldn’t stop taking this antibiotic early so that you can drink. Metronidazole is a common antibiotic often sold under the brand name Flagyl. It’s most commonly prescribed as an oral tablet, and it also comes as a vaginal suppository and a topical cream. One of the most significant indicators of addiction is the inability to convince yourself to stop doing something even when you know the results could be hazardous, even fatal.

Articles Related to Alcoholism

We understand that the treatment process can be difficult at times. At Long Island Interventions, we are committed to assisting you in making progress towards a new life free from the grips of addiction. Flagyl I.V. RTU (brand of metronidazole ready-to-use injection) contains 14 mEq of sodium per each 500 mg dose of metronidazole. The sodium content should be considered when this product is used in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention. Case report of a death attributed to combining metronidazole and alcohol.

flagyl and alcohol

However, some experts recommending waiting up tothree daysafter the last dose. To stay safe, you should also make sure your doctor knows about all of the medications you take, including over-the-counter and prescription drugs, vitamins, and herbal supplements. You should also tell your doctor if you’re pregnant or thinking about becoming pregnant. Flagyl is a common antibiotic that doctors prescribe to treat a wide range of infections. People applying the antibiotic topically should avoid alcohol throughout treatment and for 24 hours after the last application.

As a result, doctors and pharmacists generally recommend avoiding alcohol while taking Flagyl and for 3 days after the last dose because of the risk of side effects. The interactions between alcohol and Flagyl, specifically Flagyl’s inhibition of aldehyde dehydrogenase, may continue for up to 3 days after a person stops taking the antibiotic. While some people do not experience the effects of combining alcohol and Flagyl, doctors and pharmacists recommend avoiding alcohol as a precaution. Flagyl is an antibiotic that treats many infections, including abdominal and sexually transmitted infections . While not all antibiotics interact with alcohol, drinking while using certain types — including Flagyl — can have serious health consequences. Drinking alcohol while taking Flagyl can cause serious side effects.

About metronidazole and sticking with treatment

Azoles are antifungals approved for the treatment of fungal infections . To our knowledge, there are no data available on the PK/PD or efficacy of oxazolidinone. To our knowledge, there are no data available on the PK/PD or efficacy of TMP-SMX.

  • Avoid alcoholic drinks.PyrazinamideTalk with your doctor before you drink alcohol.Alcohol may increase the risk of liver disease.
  • Recent data do not support that nitrofurantoin and alcohol causes a disulfiram-like reaction or other adverse reactions/toxicities.
  • No one should assume the information provided on Addiction Resource as authoritative and should always defer to the advice and care provided by a medical doctor.
  • One patient developed heart block after taking linezolid and 7 mg of tyramine .
  • Because of this, people who drink alcohol while taking Flagyl may experience a disulfiram-like reaction.
  • Likewise the combination of Flagyl and alcohol/ metronidazole and alcohol can cause serious side effects including hot flashes, blood pressures changes and many more.

Sweating was experienced by 63%, palpitations by 78%, dizziness by 56%, hypotension in 24%, tachycardia in 76%, premature atrial beat in 4%, and premature ventricular beat in 3% . A few antibiotics — such as metronidazole , tinidazole , and sulfamethoxazole and trimethoprim — should not be mixed with alcohol because this may result in a more severe reaction. Drinking any amount of alcohol with these medications can result in side effects such as flushing, headache, nausea and vomiting, and rapid heart rate. Alcohol or metronidazole alone, and not all patients who mix metronidazole and alcohol may experience adverse effects. There have been no reports that specify the amount of alcohol consumption and dose of metronidazole that cause these side effects. Switch to water and avoid alcoholic drinks for 3 days after your last dose of Flagyl.


The basis for this recommendation is unclear, as published findings do not identify an interaction. The efficacy of azithromycin was unaffected by alcohol, as survival rates were similar in both alcohol-fed rats and control groups in the pneumococcal pneumonia rat model . Fluoroquinolones are a class of antibiotics that are approved for a variety of infections . A total of 87 studies are included in this review, after many were excluded due to duplications or not being relevant to the review (Fig. 1).

The category of drugs known as antidipsotropic are medications administered to help an alcoholic abstain from drinking. When taken with ethanol, the combination creates very unpleasant interactions, which can help individuals with chronic drinking problems to quit. This, of course, does not deter the severity of this potentially deadly combination.

flagyl and alcohol

Such individuals are then at an increased risk of damaging their organism, which has decreased self-healing properties. Mixing antibiotics and alcohol is an immensely broad topic. Having a glass of wine and necking a couple of Zynox pills can be very different from mixing a few vodka shots with Flagyl.

Drinking impairs the body’s self-healing ability by depriving it of its water and tiring it out. Drinking may not make the medications ineffective, but it slows down the recovery process. Linezolid is a weak, nonspecific inhibitor of monoamine oxidase enzymes . Studies have shown positive pressor responses in comparison with placebo with tyramine administration . One patient developed heart block after taking linezolid and 7 mg of tyramine . Per prescribing information, large quantities of beverages with a high tyramine content, including red wine and tap beers, should be avoided and limited to less than 100 mg of tyramine daily .

Metronidazole and alcohol side effects

If you are like many other people, you have taken antibiotics many times previously in your life to fight various types of infections and illnesses. While you were on these other antibiotics, you may have been able to consume an alcoholic beverage from time to time without an issue. This is because many types of antibiotics do not have strong interactions with a moderate amount of alcohol. Unfortunately, this is not the case with Flagyl and alcohol.

Managing Effects of Mixing Antibiotics with Alcohol

Even after your last dose of Flagyl, it remains in your system for some time. Flagyl may be cleared from your body within 48 hours, but the elimination rate varies depending on a person’s age and metabolism, eco sober house boston among other factors. Find out how the combination can affect your health and behavior. You usually take this drug up to three times per day for 10 days, depending on the type of infection.

It was explained that the history of Flagyl and alcohol reaction might have been strictly from the excessiveness of ethanol and its side effects. These symptoms are similar to the side effects of a drug called Disulfiram, which is used to treat alcohol dependency. When on Disulfiram, the counter effectiveness is so strong that even one drink is enough to trigger these unpleasant effects. It is crucial to dissuade alcoholics from drinking more after they have experienced these symptoms. In addition, some people may be more likely to experience adverse effects from mixing Flagyl and alcohol. For example, those who are 65 years old or older may feel more of the effects of alcohol use.

If you have liver disease or if you take other medications, you should consult with your physician before you drink alcohol again. Antibiotics work in different ways in the body, and alcohol consumption can interact with the metabolism of some antibiotics. Alcohol breaks down in the human body through a two-step process.

Does alcohol make metronidazole less effective?

Online drug information centers for Walgreen’s, Rite Aid, and CVS pharmacies were queried for each antimicrobial for concurrent alcohol use warnings . Tables are provided for ease of reference with overall recommendations for use with alcohol , recommendations with moderate strength of evidence , and recommendations with poor strength of evidence . Alcohol abuse impacts millions of people in the United States alone.